/////////////////////////////////////////////////////////////////////////////
//
// Pharmacy drug list file
//
// For a list of properties that a drug can have, see Drug.java in the // package phic.drug - they are the properties in capital letters, // representing pharmacological effects.
//
//
//
// To create a drug with a new mode of action, 3 things need to be // done:
//	1) Add the drug definition to this list, with its new property //         if required.
//	2) Add any newly defined property of the drug to the file //         Drug.java
//	3) Use the drug in the program with //         blood.getDrugConcentration(property_name)
//
//
// Common parameters
//  RENAL_REABSORPTION	(-1 to +1) fraction of reabsorption from //                      tubule or clearance from blood. Default = 0
//  SINGLE_DOSE		The usual dose that is given, in the //                      appropriate units
//  			(Default = 0.001 g)
//  HEPATIC_METABOLISM  fraction of substance metabolised as it passes //                      through the liver, (default = 0)
//  OSMOTIC_EFFECT  	number of osmoles per unit of drug (useful //                      when drugs measured in grams or units
//  FAT_SOLUBILITY	Solubility of drug in fat, in units of drug //                      per gram of fat.
//  Description 	must not contain newline characters
//  Unit  		either g, mol or U. (Default is g)
//
//////////////////////////////////////////////////////////////////////////////

[Propranolol]
Description	=Beta blocker. Used to lower blood pressure, and reduce load on the heart.
SINGLE_DOSE	=0.050
BETA_ADRENOCEPTOR	=-100
ALPHA_ADRENOCEPTOR	=0
RENAL_REABSOPTION	=-0.98
Unit		=g

[Adrenaline]
Description	=Non-selective alpha and beta adrenoreceptor agonist. Has both positive inotropic and chronotropic effects, and acts as a vasoconstrictor. Used in treating anaphylactic shock, sepsis, and cardiac arrest.
SINGLE_DOSE	=0.001
//1mg is given IM in emergencies, IV in cardiac arrest.
ALPHA_ADRENOCEPTOR	=100
BETA_ADRENOCEPTOR	=100
HEPATIC_METABOLISM	=0.9

[Noradrenaline]
Description=Selective alpha adrenoreceptor agonist. It thus has a strong vasoconstricting effect, and is used in the treatment of septic shock.
SINGLE_DOSE	=0.001
ALPHA_ADRENOCEPTOR	=150
HEPATIC_METABOLISM	=0.9


[Dobutamine]
Description	=Selective beta agonist. Positive cardiac inotrope. Useful in treating bradycardia and cardiogenic shock. It may have a renoprotective effect in shock.
SINGLE_DOSE	=0.010
BETA_ADRENOCEPTOR	=1
ALPHA_ADRENOCEPTOR	=0.2

[Ramipril]
Description	=ACE inhibitor: reduces the level of angiotensin II by preventing the conversion of angiotensin I in the lung. They can cause hyperkalaemia and impair renal perfusion.
ANGIOTENSIN_CONVERTING_ENZYME	= -1

[Spironolactone]
Description	=Aldosterone antagonist, which prevents exchange of sodium and potassium in the collecting duct.
ALDOSTERONE_RECEPTOR	=-1
SINGLE_DOSE	=0.010

[Frusemide]
Description	=Loop diuretic, that impairs reabsorption of sodium in the loop of Henle.
LOOP_REABSORPTION	=-1000
SINGLE_DOSE	=0.010
Unit		=g

[Losartan]
Description	=Angiotensin II receptor antagonist. Useful in heart failure, hypertension, post-MI. Contraindicated in renal artery stenosis.
ANGIOTENSIN_II_RECEPTOR	= -3E-5
SINGLE_DOSE	=0.025

[Desmopressin]
Description	=ADH analogue. Used for the diagnosis and treatment of cranial diabetes insipidus, and treatment of nocturnal enuresis. It also boosts factor VIII concentrations and can be used for von Willebrand's disese or variceal bleeding.
ADH_RECEPTOR		=1
SINGLE_DOSE	=0.000004
// =4 micrograms

[Hydralazine]
Description 	=An alpha blocker with general vasodilator effect, that dilates all arteries in the body.
ALPHA_ADRENOCEPTOR	=-100
SINGLE_DOSE		=0.010

[Glyceryl trinitrate]
Description	=This is a short-acting nitrate vasodilator with venodilatory properties
//extra-fast metabolism as all tissues metabolise GTN
HEPATIC_METABOLISM	=2.0
VENOUS_SMOOTH_MUSCLE	=-1.0
ALPHA_ADRENOCEPTOR	=-1000
SINGLE_DOSE		=100E-6

[Actrapid Insulin]
Description		=A compound with insulin-like effect. It is rapid acting, and metabolised faster than insulin. Is used to control blood sugar in Type I diabetes mellitus, and in ketoacidosis.

//was 2.0
INSULIN_EFFECT	=19.2e-9

Unit			=U
SINGLE_DOSE		=10

[Glucagon]
Description	= Hormone that antagonises the effects of insulin.
INSULIN_EFFECT		=-20000
SINGLE_DOSE		=0.001
//check doses

[Acetazolamide]
Description		=Carbonic anhydrase inhibitor. Carbonic anhydrase is the enzyme that catalyses the conversion of CO2 and water to give carbonic acid, H2CO3. This is necessary for bicarbonate secretion in the  kidney, aqueous humour production and CSF secretion. *not implemented
//not implemented yet

[Paraaminohippuric acid]
Description		=This is a chemical that is completely cleared in the kidney; i.e. there should be none left in the renal vein. It can thus be used to estimate renal blood flow.
RENAL_REABSORPTION		=-1.0
SINGLE_DOSE			=1.0

[Inulin]
Description=Inulin is a carbohydrate that is not reabsorbed nor secreted by the kidney. It may therefore be used to measure the glomerular filtration rate.
SINGLE_DOSE=1.0

[Demeclocycline]
Description		=This reduces the effect of ADH, and can be used in the treatment of SIADH, if water restriction fails.
ADH_RECEPTOR		=-1E-3
SINGLE_DOSE		=0.010

[Mannitol]
Description		=Mannitol is a sugar which can be used as an osmotic diuretic: as it is excreted by the kidney, it draws water with it by its osmotic effect. May be used to treat cerebral oedema, as it removes more water than salt.
OSMOTIC_EFFECT			=1.0
SINGLE_DOSE			=5.0

[Morphine]
Description=Morphine is an analgesic, sedative, emetic, a respiratory depressant, venodilator, and reduces gut motility. It works by binding to opiate receptors.
SINGLE_DOSE=0.005
RENAL_REABSORPTION=0.9
HEPATIC_METABOLISM=0.5
MU_OPIATE_RECEPTOR=1
VENOUS_SMOOTH_MUSCLE=-0.01

[Propofol]
Description=Propofol is commonly used to induce and maintain anaesthesia. It is thought to act by opening GABA receptor chloride channels, and is highly lipid soluble.
SINGLE_DOSE=0.050
RENAL_REABSORPTION=0.9
HEPATIC_METABOLISM=0.1
MU_OPIATE_RECEPTOR=0.1
GABA_RECEPTOR=0.5
LIPID_SOLUBILITY=10

[Alcohol]
Description=Ethanol, or ethyl alcohol, has mild diuretic and sedative effects.
SINGLE_DOSE=0.025
Unit=g
HEPATIC_METABOLISM=0.15
RENAL_REABSORPTION=0.98
GABA_RECEPTOR=0.02
LIPID_SOLUBILITY=1.6
ADH_RECEPTOR=-1E-8

[Interferon]
Description=This is an inflammatory cytokine that causes fever and vasodilatation.
SINGLE_DOSE=0.010
RENAL_REABSORPTION=0.99
HEPATIC_METABOLISM=0.5
//ALPHA_ADRENOCEPTOR=-1000 //vasodilator effect counteracts fever!
INFLAMMATORY_ACTIVITY=1

