Wegeners granulomatosis

external

• Synonyms

  • Granulomatosis with polyangiitis

• Causes

  • HLA-B27

• Effects

  • Rhinitis
  • Cough
  • Epistaxis
  • Oral ulcer
  • Necrotising microvascular glomerulonephritis
  • Rapidly progressing glomerulonephritis
  • Pulmonary haemorrhage
  • Gum hyperplasia
  • Proptosis
  • Scleritis
  • Episcleritis
  • Positive c-ANCA
  • Pyoderma gangrenosum
  • Cavitating lung lesion
  • Scleromalacia perforans
  • Mononeuritis multiplex
  • Saddle nose
  • Retro-orbital mass
  • Nail-fold vasculitis
  • Non-caseating granuloma
  • Acute otitis media

• Parents

  • Primary vasculitis
  • Conjunctivitis

• Children

  • Midline granuloma

• Description

  • "5yr mortality 30% Rx Pred + cyclophosphamide
  • or azathioprine"