Tricyclic antidepressant

external

• Synonyms

  • TCA

• Effects

  • Antimuscarinic drug
  • Neuromuscular blockade
  • Prolonged QT interval
  • Neuroleptic malignant syndrome
  • Intestinal pseudoobstruction
  • Inappropriate ADH secretion
  • Cholestasis
  • Restless legs syndrome
  • Ventricular tachyarrhythmia
  • Weight gain

• Parents

  • Noradrenaline reuptake inhibitor
  • Alpha adrenoceptor blocker
  • Antihistamine
  • Antimuscarinic drug

• Children

  • Amitriptyline
  • Imipramine
  • Clomipramine
  • Desipramine

• Treats

  • Depression

• Description

  • "Overdose can cause VT: Rx bicarbonate and amiodarone. Tricyclis are potent antihistaminics. The severe morbidity and mortality associated with these drugs is well documenteddue to their cardiovascular and neurological toxicity"