Transitional cell carcinoma of bladder

external

• Synonyms

  • TCC of bladder
  • Bladder TCC

• Causes

  • Cigarette smoking
  • Dye
  • Cyclophosphamide
  • Pelvic irradiation

• Effects

  • Haematuria

• Parents

  • Carcinoma of urinary bladder

• Children

  • Non invasive transitional cell carcinoma of bladder
  • Invasive transitional cell cancer of urinary tract
  • Carcinoma in situ of bladder

• Description

  • "STAGING Ta Mucosal T1 Invades Lamina Propria T2 Invades superficial muscle T3 Invades deep muscle T4 Adjacent organ spread PROGNOSIS: 5 yr survival Ta = 95% T1 = 70% T2 = 60% T3 = 40% T4 = 10% Prognostic factors: � Depth of invasion. � Pathologic grade � Presence of carcinoma in situ. 10% of bladder TCCs develop TCC in the ureter or kidney later. TREATMENT: Ta - Cystodiathermy + Intravesical Mitomycin T1 - TURBT + Intravesical BCG T2-T3 = Radical Cystectomy/ Radiotherpay T4 - Paliative Radiotherpay"