Thyrotoxicosis

external

• Synonyms

  • Hyperthyroidism
  • Thyrotoxic syndrome

• Causes

  • Graves disease
  • Multinodular goitre
  • Thyroid adenoma
  • Thyrotrophin-secreting pituitary adenoma
  • Thyroxine
  • Subacute thyroiditis
  • Amiodarone
  • High human chorionic gonadotrophin
  • Post-partum thyroiditis
  • Struma ovarii
  • Polyostotic fibrous dysplasia

• Effects

  • Increased Basal Metabolic rate
  • Sweaty palm
  • Sinus tachycardia
  • Atrial fibrillation
  • Physiological tremor
  • Metabolic neuropathy
  • Proximal myopathy
  • Increased gut motility
  • Lid lag
  • Lid retraction
  • Hypertension
  • Hypercalcaemia
  • Osteoporosis
  • Thyroid Crisis
  • Hypokalaemic periodic paralysis
  • High total thyroxine
  • Low thyroid stimulating hormone
  • Onycholysis
  • Increased vitamin B12 requirement
  • Hypothalamic-pituitary-ovarian axis malfunction
  • Myxoid degeneration
  • Gynaecomastia
  • Impotence
  • Splenomegaly
  • Fasciculation
  • Hypogammaglobulinaemia
  • Late puberty
  • Telangiectasia
  • Tall stature
  • Lag storage curve
  • High cardiac output state
  • Sweating
  • Fetal tachycardia
  • Organic mood disorder
  • Hypercatabolic state
  • Fever of unknown origin
  • Fever
  • Night sweats
  • Weight loss

• Parents

  • Thyroid disease
  • Acquired metabolic disease

• Treatments

  • Carbimazole
  • Radioiodine therapy
  • Thiouracil

• Description

  • "30% have proximal myopathy"