Systemic lupus erythematosus

external

• Synonyms

  • SLE

• Causes

  • Anti-dsDNA antibody
  • Anti-Smith antibody
  • Antinuclear antibody
  • Anti-snRNP
  • HLA-B27
  • Hydralazine
  • Procainamide
  • Penicillamine
  • Antihistone antibody
  • Anti-Ro antibody
  • Anti-La antibody
  • HLA-DR3
  • C1R deficiency
  • African origin
  • Female gender

• Effects

  • Butterfly rash
  • Photosensitivity
  • Raynaud phenomenon
  • Lupus nephropathy
  • Warm antibody haemolysis
  • Microangiopathic haemolytic anaemia
  • Migratory polyarthritis
  • Antiphospholipid syndrome
  • Antiplatelet antibody
  • Increased neutrophil destruction
  • Pancytopaenia
  • Discoid lupus erythematosus
  • Mononeuritis multiplex
  • Noninfective meningitis
  • Mitral valve prolapse
  • Libmann-Sachs endocarditis
  • Miscarriage
  • Shrinking lung
  • Type III cryoglobulinaemia
  • Secondary nephrotic glomerular disease
  • Pyoderma gangrenosum
  • Erythema multiforme
  • Acquired complement deficiency
  • Livedo reticularis
  • Acute pancreatitis
  • Basal lung fibrosis
  • Aphthous ulcer
  • Autoimmune conjunctivitis
  • Scleritis
  • Serositis
  • Monospot test positive
  • Cerebral vasculitis
  • Mitral stenosis
  • Aortic stenosis
  • Avascular necrosis
  • Insulin autoantibodies
  • Roth spots
  • Optic neuritis

• Parents

  • Collagen vascular disease

• Children

  • Drug-induced lupus

• Description

  • "60% have dsDNA 40% have anti-Sm 20% have Anti-Ro and La 50% have Raynaud phenomenon 40% have Antiphospholipid syndrome"