Systemic amyloidosis

external

• Synonyms

  • Amyloidosis
  • Amyloid disease

• Causes

  • Immunocyte dyscrasia
  • Monoclonal gammopathy of unknown significance
  • Familial amyloidotic polyneuropathy

• Effects

  • Fragile blood vessel
  • Renal amyloidosis
  • Macroglossia
  • Splenomegaly
  • Metabolic neuropathy
  • Autonomic neuropathy
  • Paraproteinaemia
  • Infiltrative cardiomyopathy
  • Mucocutaneous petaechiae
  • Intestinal pseudoobstruction
  • Carpal tunnel syndrome
  • Adrenocortical insufficiency
  • Protein-losing enteropathy
  • Small fibre neuropathy
  • Cutis laxa
  • Hyposplenism

• Parents

  • General pathology

• Children

  • Amyloid light chain
  • Amyloid precursor protein
  • Secondary amyloidosis
  • Raised beta-2 microglobulin
  • Raised amyloid A protein
  • Transthyretin-related familial amyloid polyneuropathy

• Description

  • "Deposition of normally-soluble protein"