Splenomegaly

external

• Causes

  • Infectious mononucleosis
  • Haematological malignancy
  • Portal hypertension
  • Extravascular haemolysis
  • Sarcoidosis
  • Splenic response to infection
  • Myeloproliferative disorder
  • Connective tissue disease
  • Thalassaemia
  • Hereditary spherocytosis
  • Idiopathic thrombocytopaenic purpura
  • Systemic amyloidosis
  • Increased red cell turnover
  • Iron deficiency anaemia
  • Gaucher disease
  • Niemann-Pick disease
  • Felty syndrome
  • Weil disease
  • Wolman disease
  • Griscelli syndrome
  • Thyrotoxicosis
  • Haemophagocytosis syndrome
  • Type I hyperlipoproteinaemia
  • Hypereosinophilic syndrome
  • Fucosidosis
  • AIDS with mycobacterium avium complex
  • Chronic granulomatous disease
  • Splenic vein thrombosis

• Effects

  • Platelet sequestration
  • Increased neutrophil destruction
  • Pancytopaenia
  • Dullness in Traub's space

• Parents

  • Organomegaly

• Children

  • Massive splenomegaly
  • Moderate splenomegaly
  • Mild splenomegaly