Retinoblastoma

external

• Causes

  • RB1 gene mutation

• Effects

  • Leucocoria
  • Nystagmus
  • Decreased visual acuity
  • Enucleation
  • Cancers due to gene mutation
  • Acquired strabismus
  • Flexner-Wintersteiner rosettes

• Parents

  • Autosomal dominant disorder
  • Childhood malignancy

• Treatments

  • Laser therapy
  • Enucleation

• Description

  • "age< 3yrs 50% are inherited. Maybe bilateral. Spread: Direct- along optic nerve to brain. Blood spread to bones"