Progressive supranuclear palsy

external

• Synonyms

  • PSP
  • Richardson-Steele-Olzewski disease
  • Steele-Richardson-Olszewski syndrome
  • SRO syndrome
  • RSO syndrome

• Causes

  • Tau protein mutation

• Effects

  • Parkinsonism
  • Axial rigidity
  • Impaired vertical saccades
  • Impaired optokinetic nystagmus
  • Impaired smooth pursuit
  • Dysarthria
  • Dysphagia
  • Mental slowing
  • Echolalia
  • Palilalia
  • Applause sign
  • Backward falls
  • Frontal release
  • Gait apraxia

• Parents

  • Neurodegenerative disorder
  • Tauopathy

• Description

  • "Prevalence 1.4 per 100
  • 000 Onset at 60 years Mean survival 6 years Poor response to levodopa"