Polyostotic fibrous dysplasia

external

• Causes

  • McCune Albright syndrome
  • Mutation GNAS1

• Effects

  • Pathological fracture
  • Short stature
  • Scoliosis
  • Facial dysmorphism
  • Cafe au lait patch
  • Precocious puberty
  • Increased growth hormone secretion
  • Thyrotoxicosis
  • Cushing syndrome
  • Hypophosphataemia
  • Osteomalacia
  • Optic nerve compression
  • Looser's zone
  • Osteosarcoma0.0%
  • Leontiasis ossea

• Parents

  • Congenital skeletal dysplasia

• Treatments

  • Bisphosphonate
  • anti-androgens
  • Anti-oestrogen