Pernicious anaemia

external

• Synonyms

  • Autoimmune atrophic gastritis
  • Addisonian pernicious anaemia

• Causes

  • Endocrine autoimmune disease
  • Anti-parietal cell antibody
  • Anti-intrinsic factor antibody
  • HLA-DR5
  • Type I polyglandular syndrome
  • Type II polyglandular syndrome
  • Type III polyglandular syndrome
  • Scandinavian descent

• Effects

  • Intrinsic factor deficiency
  • Achlorhydria
  • Bone marrow suppression
  • High gastrin level
  • Shilling test positive
  • Gastric adenocarcinoma
  • Malignant transformation

• Parents

  • Autoimmune bowel disease

• Description

  • "50% have antibodies to intrinsic factor 5% have adenoCa at diagnosis (threefold incidence)"