Pemphigus vulgaris

external

• Synonyms

  • Pemphigus

• Causes

  • Anti-desmoglein
  • Ashkenazi Jew
  • Indian origin
  • Mediterranean origin
  • Lymphoma

• Effects

  • Bulla
  • Oral ulcer
  • Koebner phenomenon

• Parents

  • Autoimmune skin disease
  • Ten serious rashes

• Treatments

  • Immunosuppressant drug
  • Mycophenolate mofetil
  • Glucocorticoid

• Description

  • "antibodies against desmogleins
  • which disrupt connections between epidermal squamous cells. 50% have oral involvement Serious condition: Untreated 80% will die in a year. Greek 'pemphix' = blister"