Panhypopituitarism

external

• Causes

  • Pituitary adenoma
  • Pituitary surgery
  • Craniopharyngioma
  • Meningioma
  • Sheehan post-partum pituitary necrosis
  • Subarachnoid haemorrhage
  • Pituitary apoplexy
  • Miliary tuberculosis
  • Haemochromatosis
  • Type II polyglandular syndrome
  • Langerhans cell histiocytosis

• Effects

  • Low thyroid stimulating hormone
  • Hypothyroidism
  • Amenorrhoea
  • Breast atrophy
  • Adrenocortical insufficiency
  • Low growth hormone
  • Cranial diabetes insipidus

• Parents

  • Pituitary disease
  • Congenital endocrine disorder