Paget disease

external

• Synonyms

  • Paget's disease of bone
  • Osteitis deformans
  • Osteodystrophia deformans

• Effects

  • Bone pain
  • Sclerosis of bone
  • Sabre tibia
  • Vestibulocochlear nerve palsy
  • Optic nerve compression
  • Jugular foramen syndrome
  • Hip fracture
  • High alkaline phosphatase
  • Hypercalcaemia
  • High cardiac output state
  • Osteoporosis circumscripta
  • Osteosarcoma
  • Degenerative valve calcification
  • Angioid streak
  • Looser's zone
  • Dupuytren's contracture
  • Macrognathia
  • Leontiasis ossea
  • Congenital skeletal dysplasia
  • Osteolysis

• Parents

  • Metabolic bone disease

• Treatments

  • Calcitonin
  • Mithramycin
  • Bisphosphonate

• Description

  • "Incidence 3% over 55 enlarged and misshapen bones. - excessive breakdown and formation of bone
  • followed by - disorganized bone remodelling"