Myelofibrosis

external

• Causes

  • Polycythaemia rubra vera
  • JAK2 gene mutation

• Effects

  • Bone marrow infiltration
  • Pyoderma gangrenosum
  • Acellular bone marrow
  • Raised leucocyte alkaline phosphatase
  • Poikilocytosis

• Parents

  • Myeloproliferative disorder