Myelodysplastic syndrome

external

• Synonyms

  • Myelodysplasia
  • MDS

• Causes

  • Irradiation

• Effects

  • Ineffective granulopoiesis
  • Bone marrow infiltration
  • Lymphocytosis
  • Monocytosis
  • Atypical monocytes
  • Transfusion-dependent anaemia
  • Macrocytosis
  • Acute myeloid leukaemia
  • Sweet disease
  • Ringed sideroblast
  • Schistocytosis
  • Pelger-Huet neutrophil
  • Positive Ham's test

• Parents

  • Haematological malignancy

• Children

  • Refractory anaemia
  • Refractory anaemia with ringed sideroblasts
  • Refractory anaemia with excess of blasts
  • Chronic myelomonocytic anaemia

• Treatments

  • Multiple transfusion

• Description

  • "Heterogeneous group of conditions
  • mainly clonal neoplasms. Incidence 22 in 100
  • 000 over the age of 70 Commonly have deletions of 5q- (GM-CSF gene)"