Megaloblastic anaemia

external

• Causes

  • Vitamin B12 deficiency
  • Folic acid deficiency
  • Di Gugliemo syndrome
  • Uridine monophosphate synthase deficiency
  • Tropical sprue

• Effects

  • Macrocytosis
  • Ovalocytosis
  • Leukopaenia
  • Hypersegmented granulocytes
  • Erythroid precursor
  • Decreased platelet production
  • Ineffective granulopoiesis
  • Megaloblast
  • High liver dehydrogenase

• Parents

  • Anaemia of reduced erythropoiesis
  • Anaemia
  • Macrocytic anaemia