"Loss of control of intracellular calcium ions in skeletal muscle - Increases free ionised intracellular calcium to damaging levels.
Primary defect not known.
triggered by :
-volatile anesthetic agents(halothane).
-depolarizing muscle relaxants (succinylcholine).
nondepolarizing muscle relaxants (pancuronium)
do not cause MH.
Dantrolene and the avoidance of inhaled anesthesia in susceptible people have markedly reduced the mortality by 80% .
Prophylactic Dantrolene not recommended because of its adverse effect of prolonging the action of depolarising muscle relaxants."