Inappropriate ADH secretion

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• Synonyms

  • SIADH
  • Secretion of inappropriate ADH
  • Excess arginine vasopressin
  • Secretion of inappropriate AVP
  • Inappropriate arginine vasopressin secretion
  • Syndrome of inappropriate antidiuretic hormone

• Causes

  • Bronchial carcinoma
  • Mesothelioma
  • Head injury
  • Subarachnoid haemorrhage
  • Cerebrovascular accident
  • Meningitis
  • Pituitary adenoma
  • Lung abscess
  • Guillain-Barre syndrome
  • Multiple sclerosis
  • Carcinoma of pancreas
  • Carcinoma of urinary bladder
  • Streptococcus pneumoniae
  • Mycoplasmal pneumonia
  • Neuroendocrine tumour
  • Chlorpropramide
  • Clofibrate
  • Cyclophosphamide
  • Vincristine
  • Tricyclic antidepressant
  • Carbamazepine
  • Thiazide
  • Ecstasy
  • Legionella
  • Sick cell syndrome
  • Emotional stress
  • Extensive surgery
  • Lymphoma
  • Leukaemia
  • Thymoma
  • Porphyria

• Effects

  • Hyponatraemia
  • Endocrine fluid retention
  • Increased vascular tone

• Parents

  • Endocrine disease
  • Acquired metabolic disease

• Treatments

  • Demeclocycline