High plasma urate

external

• Synonyms

  • Hyperuricaemia
  • High plasma uric acid

• Causes

  • Increased red cell turnover
  • Pre-eclampsia
  • Myeloma renal disease
  • Tumour lysis syndrome
  • Myeloproliferative disorder
  • Lymphoproliferative disorder
  • Chemotheraputic drug
  • Haemolysis
  • Pregnancy
  • Chronic renal failure
  • Chronic infection
  • Increased purine turnover
  • Decreased urate clearance
  • Psoriasis
  • Metabolic acidosis
  • Thiazide
  • Aspirin
  • Cyclosporin
  • Ethambutol
  • Pyrazinamide
  • Hypothyroidism
  • Hypoparathyroidism
  • Hyperparathyroidism
  • Lead poisoning
  • Lesch Nyhan syndrome
  • Von Gierke disease
  • Obesity
  • Alcoholism
  • Erythroderma
  • Adenine phosphoribosyltransferase deficiency
  • Phosphoribosylpyrophosphate synthetase superactivity

• Effects

  • Tubulointerstitial nephritis
  • Gout
  • Uric acid stone

• Parents

  • Biochemical investigation
  • Acquired metabolic disease