"Predominantly children.
Preceded by water or foodborne infection.
Mortality 10%
higher in adults.
Pathology:
Microangiopathy. Renal endolthelial vascular damage.
Clumping of platelets in kidney. Blood flow reduced.
Partial blockage of blood vessels also leads to destruction of red cells (hemolysis) - the effects on red cells are similar to throwing a
tomato through chicken wire.
Cause of hemolytic uremic syndrome in adults is often unknown. "