Guillain-Barre syndrome

external

• Synonyms

  • GBS
  • Acute inflammatory demyelinating polyneuropathy
  • AIDP
  • Guillain-Barr� syndrome

• Causes

  • Epstein Barr virus
  • Surgery
  • Human immunodeficiency virus
  • Cytomegalovirus
  • Campylobacter jejuni
  • Mycoplasma pneumoniae
  • Anti-GM2 antibody
  • Anti-GalC antibody

• Effects

  • Demyelination of peripheral nerve
  • Mainly motor neuropathy
  • Neuromuscular hypoventilation
  • Bulbar palsy
  • Elevated protein in CSF
  • Motor conduction block
  • Autonomic dysreflexia
  • Inappropriate ADH secretion
  • Oligoclonal bands in CSF

• Parents

  • Neuropathy
  • Autoimmune neurological disease

• Children

  • Miller-Fisher syndrome7.0%
  • Acute motor axonal neuropathy

• Treatments

  • Plasmapheresis
  • Intravenous immunoglobulin

• Description

  • "Symmetrical. 85% complete recovery 10% unable to walk after 1 year 10% mortality Nadir < 4/52
  • mean < 9/7"