Darier disease

external

• Synonyms

  • Darrier disease
  • Darier White disease
  • Darier's disease

• Causes

  • ATP2A2 gene mutation

• Effects

  • Pruritus
  • Palmar pitting
  • V-shaped nail defects
  • Greasy yellow papules
  • Koebner phenomenon

• Parents

  • Autosomal dominant disorder
  • Disorder of keratinsation
  • Congenital skin disease

• Treatments

  • Isotretinoin

• Description

  • "Locus 12q24.11 Disorder of keratinisation. Lack desmosomes- the junction that binds cells together. Keratinization occurs more frequently in seborrhoeic areas "