Cholestasis

external

• Synonyms

  • Biliary obstruction
  • Obstructive jaundice

• Causes

  • Cholestasis of pregnancy
  • Common bile duct obstruction
  • Phenothiazine
  • Oestradiol
  • Erythromycin
  • Sulphonamide
  • Tricyclic antidepressant
  • Cyclosporin
  • Azathioprine
  • Nifedipine
  • Chlorpropramide
  • Nitrofurantoin
  • HELLP syndrome
  • HMG-CoA reductase inhibitor
  • Cirrhosis
  • GRACILE syndrome

• Effects

  • Conjugated hyperbilirubinaemia
  • Steatorrhoea
  • Vitamin K deficiency
  • Ascending cholangitis
  • Secondary biliary cirrhosis
  • Hypercholesterolaemia
  • Secondary hyperlipidaemia
  • High alkaline phosphatase
  • High aspartate aminotransferase
  • High alanine aminotransferase
  • Target cells
  • Kayser-Fleischer ring

• Treatments

  • Endoscopic retrograde cholangiopancreatography