Carcinoma of breast

external

• Synonyms

  • Breast cancer
  • Ca breast

• Causes

  • Nulliparity
  • Early menarche
  • Late menopause
  • Polygenic inheritance
  • Oral contraceptive pill
  • Hormone replacement therapy
  • Klinefelter syndrome
  • Peutz-Jegher syndrome
  • Obesity
  • Membranous glomerulonephritis
  • BRCA2 gene mutation
  • Li-Fraumeni syndrome
  • Cowden disease

• Effects

  • Breast lump
  • Peau d'orange
  • Nipple discharge
  • Paget disease of nipple
  • Lung metastasis
  • Liver metastasis
  • Bone metastasis
  • Weight loss
  • Hypercalcaemia
  • Ectopic parathyroid hormone secretion
  • Secondary ovarian tumour
  • Membranous glomerulonephritis
  • Dermatomyositis
  • Homocysteinaemia
  • Epithelial ovarian tumour
  • Krukenberg tumour
  • Cancers due to gene mutation

• Parents

  • Breast disease
  • Carcinoma

• Treatments

  • Mastectomy
  • Lumpectomy
  • Irradiation
  • Brachytherapy
  • Tamoxifen
  • Chemotheraputic drug
  • Radiotherapy
  • Trastuzumab
  • Aminoglutethimide
  • Ifosfamide
  • Weight loss

• Description

  • "SPREAD: 1. Local - skin
  • chest wall 2. Lymphatics - axillary nodes internal mammarynodes supraclavicular 3. Blood - Liver Lung Bone 4. Transcoelomic - peritoneal deposits 5YR SURVIVAL: Ductal carcinoma in situ = 98% Lymph node mets= 84%. Distant mets =27%. "