Barrett's oesophagus

external

• Causes

  • Gastrooesophageal reflux disease
  • Male gender
  • Caucasian

• Effects

  • Carcinoma of oesophagus
  • Dysphagia
  • Nausea and vomiting
  • Upper gastrointestinal bleed
  • Malignant transformation

• Parents

  • Upper gastrointestinal pathology

• Description

  • "Premalignant condition: 40-fold risk of adenocarcinoma Male: female = 10:1 Caucasian: African = 5:1 Pathology: Squamous to columnar metaplasia in lower esophagus- (an adaptation to chronic acid exposure from reflux ) Treatment 1) Annual surveillance to detect progression to intraepithelial neoplasia. 2)For such high-grade dysplasia: - esophagectomy or - endoscopic mucosal ablation 85% mortality if oesophageal cancer develops."