Aplastic anaemia

external

• Synonyms

  • Bone marrow aplasia

• Causes

  • Immunological bone marrow destruction
  • Alkylating agent
  • Antimetabolite
  • Benzene
  • Carbimazole
  • Chloramphenicol
  • Phenylbutazone
  • Mesalazine
  • Arsenic
  • Irradiation
  • Hepatitis C
  • Hepatitis A
  • Epstein Barr virus
  • Cytomegalovirus
  • Parvovirus
  • Fanconi anaemia
  • Mycobacterium avium intracellulare
  • Haemophagocytosis syndrome
  • Potassium perchlorate
  • Felbamate
  • Ethosuximide

• Effects

  • Neutropenia
  • Decreased platelet production
  • Ineffective granulopoiesis
  • Aplastic crisis

• Parents

  • Bone marrow failure anaemia

• Treatments

  • Blood transfusion
  • Bone marrow transplant
  • Antithymocyte immunoglobulin

• Description

  • "Myeloid bone marrow failure Average age 25 Incidence 2 per 1
  • 000
  • 000 per year Usually idiopathic Fatal untreated but 70% 5-year survival with treatment"