Amiodarone

external

• Effects

  • Amiodarone-induced pulmonary toxicity
  • Thyrotoxicosis
  • Hypothyroidism
  • Cornea verticillata
  • Clouding of vision
  • Orange tears
  • Chemical cardioversion
  • Photosensitivity
  • Blue-grey skin pigmentation
  • Drug-induced hepatitis
  • Raised thyroid stimulating hormone
  • Digoxin toxicity

• Parents

  • Class III antiarrhythmic drug
  • P450 enzyme inhibitor
  • Drug secreted in breast milk

• Treats

  • Cardiac arrest
  • Dilated cardiomyopathy
  • Hypertrophic cardiomyopathy

• Description

  • "Causes hypothyroidism by Wolff-Chaikoff effect Causes hyperthyroidism by Jod Basedow phenomenon Contains 37% iodine 10% is deiodinated per day 70% removed through biliary excretion "