Addison disease

external

• Synonyms

  • Addison's disease
  • Autoimmune adrenalitis

• Causes

  • HLA-B8
  • HLA-DR3
  • Endocrine autoimmune disease
  • Type I polyglandular syndrome
  • Type II polyglandular syndrome
  • Adrenomyeloneuropathy35.0%

• Effects

  • Adrenocortical insufficiency
  • Hypotension
  • Postural hypotension
  • Generalised hyperpigmentation
  • Addisonian crisis
  • Muscle weakness
  • Myalgia
  • Weight loss
  • Anorexia
  • Calcified Pinna
  • Type IV renal tubule acidosis
  • Eosinophilia

• Parents

  • Endocrine disease
  • Acquired metabolic disease

• Description

  • "Hyperpigmentation of areas not exposed to sun. -skin creases -buccal mucosa"