"High growth hormone.
Bone and soft-tissue overgrowth
Incidence 3 per million per year
Prevalence 40 per million
DIAGNOSIS
Oral 75g glucose tolerance test fails to suppress GH to below 2 mU/L within 2 hrs
COMPLICATIONS
-diabetes mellitus
-hypertension
-cardiovascular disease
PROGNOSIS
- complications reduce lifespan by 10 years
- mortality rate = 2 times the rate in the general pop.
COMPLICATIONS
-diabetes mellitus
-hypertension
-cardiovascular disease
PROGNOSIS
- complications reduce lifespan 10 years
- mortality rate = 2 x general pop.
- complications reduced with treatment.
- cure reverses increased mortality.
Rx
transsphenoidal surgery